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pentobarbital will decrease the extent or influence of pantoprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can cut down panobinostat amounts by ~70% a